Mulligan, Aisling; Anney, Richard J.L.; O´Reagan, Myra; Chen, Wai; Butler, Louise; Fitzgerald, Michael; Buitelaar, Jan K.; Steinhausen, Hans-Christoph; Rothenberger, Aribert; Minderaa, Ruud; Nijmeijer, Judith; Hoekstra, Pieter J.; Oades, Robert D.; Roeyers, Herbert; Buschgens, Cathelijne; Gill, Michael et al:
Autism symptoms in Attention-Deficit/Hyperactivity Disorder: a familial trait which correlates with conduct, oppositional defiant, language and motor disorders
In: Journal of Autism and Developmental Disorders : devoted to all severe psychopathologies in childhood., Vol. 39 (2009), No. 2, pp. 197 - 211
2009article/chapter in journalOA Green
MedicineFaculty of Medicine » Essen University Hospital » LVR-Klinikum Essen » Klinik für Psychiatrie, Psychosomatik und Psychotherapie des Kindes- und Jugendalters
Title in English:
Autism symptoms in Attention-Deficit/Hyperactivity Disorder: a familial trait which correlates with conduct, oppositional defiant, language and motor disorders
Author:
Mulligan, Aisling;Anney, Richard J.L.;O´Reagan, Myra;Chen, Wai;Butler, Louise;Fitzgerald, Michael;Buitelaar, Jan K.;Steinhausen, Hans-Christoph;Rothenberger, Aribert;Minderaa, Ruud;Nijmeijer, Judith;Hoekstra, Pieter J.;Oades, Robert D.UDE
GND
1208788639
LSF ID
29685
ORCID
0000-0001-6151-5559ORCID iD
Other
connected with university
;
Roeyers, Herbert;Buschgens, Cathelijne;Christiansen, Hanna;Franke, Barbara;Gabriels, Isabel;Hartman, Catharina;Kuntsi, Jonna;Marco, Rafaela;Meidad, Sheera;Müller, Ueli;Psychogiou, Lamprini;Rommelse, Nanda N.J.;Thompson, Margaret;Uebel, Henrik;Banaschewski, Tobias;Ebstein, Richard;Eisenberg, Jacques;Manor, Iris;Miranda, Ana;Mulas, Fernando;Sergeant, Joseph A.;Sonuga-Barke, Edmund;Asherson, Philip;Faraone, Stephen V.;Gill, Michael
Year of publication:
2009
Open Access?:
OA Green
DuEPublico 1 ID

Abstract:

It is hypothesised that autism symptoms are present in Attention-Deficit/Hyperactivity Disorder (ADHD), are familial and index subtypes of ADHD. Autism symptoms were compared in 821 ADHD probands, 1050 siblings and 149 controls. Shared familiality of autism symptoms and ADHD was calculated using DeFries-Fulker analysis. Autism symptoms were higher in probands than siblings or controls, and higher in male siblings than male controls. Autism symptoms were familial, partly shared with familiality of ADHD in males. Latent class analysis using SCQ-score yielded five classes; Class 1(31%) had few autism symptoms and low comorbidity; Classes 2–4 were intermediate; Class 5(7%) had high autism symptoms and comorbidity. Thus autism symptoms in ADHD represent a familial trait associated with increased neurodevelopmental and oppositional/conduct disorders.