Kaiser, Markus; Siciliano, Carlo; Assfalg-Machleidt, Irmgard; Groll, Michael; Milbradt, Alexander G.; Moroder, Luis:
Synthesis of a TMC-95A ketomethylene analogue by cyclization via intramolecular Suzuki coupling.
In: Organic Letters, Vol. 5 (2003), No. 19, pp. 3435 - 3437
2003article/chapter in journal
Biology
Related: 1 publication(s)
Title:
Synthesis of a TMC-95A ketomethylene analogue by cyclization via intramolecular Suzuki coupling.
Author:
Kaiser, MarkusUDE
LSF ID
52590
ORCID
0000-0002-6540-8520ORCID iD
Other
connected with university
;Siciliano, Carlo;Assfalg-Machleidt, Irmgard;Groll, Michael;Milbradt, Alexander G.;Moroder, Luis
Year of publication:
2003
WWW URL:
http://pubs.acs.org/doi/full/10.1021/ol035178f
Appears in
Organic Letters
Title in English (abbreviated):
Org. Lett.
Publisher:
American Chemical Society
in:
Vol. 5 (2003), No. 19, pp. 3435 - 3437
ISSN
1523-7052 Show availability online & print
ISSN
1523-7060 Show availability online & print
ZDB ID
1501522-1
ZDB ID
1458039-1

Abstract:

A TMC-95A analogue extended at the C-terminus with NlePsi[COCH(2)]Gly-Ala-Ala-NH(2) was synthesized via side-chain cyclization of the linear precursor by a Suzuki cross-coupling reaction in solution to analyze the effect of additional P' residues on the inhibitory potency against yeast proteasome.