Meyer, Hemmo; Kondo, Hisao; Warren, Graham:
The p47 co-factor regulates the ATPase activity of the membrane fusion protein, p97
In: FEBS Letters, Jg. 437 (1998), Heft 3, S. 255 - 257
1998Artikel/Aufsatz in Zeitschrift
Biologie
Damit verbunden: 1 Publikation(en)
Titel:
The p47 co-factor regulates the ATPase activity of the membrane fusion protein, p97
Autor*in:
Meyer, HemmoUDE
GND
1089446616
LSF ID
51479
ORCID
0000-0003-1883-1796ORCID iD
Sonstiges
der Hochschule zugeordnete*r Autor*in
;
Kondo, Hisao;Warren, Graham
Erscheinungsjahr:
1998

Abstract:

The highly conserved ATPase p97, a member of the AAA-ATPases, is found in a complex with its co-factor p47 in rat liver cytosol. Previously it had been shown that p97-mediated reassembly of Golgi cisternae from mitotic Golgi fragments requires p47 which mediates the binding of p97 to a Golgi t-SNARE (soluble N-ethylmaleimide-sensitive factor attachment factor receptor), syntaxin 5. Here we show that it also suppresses the ATPase activity of p97 by up to 85% in a dose-dependent and saturable manner suggesting that it has other roles in the membrane fusion cycle.