The p47 co-factor regulates the ATPase activity of the membrane fusion protein, p97
In: FEBS Letters, Vol. 437 (1998), No. 3, pp. 255 - 257
Title:
The p47 co-factor regulates the ATPase activity of the membrane fusion protein, p97
Author:
Meyer, HemmoUDE
- GND
- 1089446616
- LSF ID
- 51479
- ORCID
-
0000-0003-1883-1796
- Other
- connected with university
Year of publication:
1998
Appears in
Place of publication:
Hoboken
Publisher:
Wiley-Blackwell
in:
Vol. 437 (1998), No. 3, pp. 255 - 257
ISSN
ISSN
ZDB ID
Library shelfmark:
Abstract:
The highly conserved ATPase p97, a member of the AAA-ATPases, is found in a complex with its co-factor p47 in rat liver cytosol. Previously it had been shown that p97-mediated reassembly of Golgi cisternae from mitotic Golgi fragments requires p47 which mediates the binding of p97 to a Golgi t-SNARE (soluble N-ethylmaleimide-sensitive factor attachment factor receptor), syntaxin 5. Here we show that it also suppresses the ATPase activity of p97 by up to 85% in a dose-dependent and saturable manner suggesting that it has other roles in the membrane fusion cycle.