Rensing, Stephan; Schrader, Thomas:
The First Synthetic Receptor for the RGD Sequence.
In: Organic Letters, Jg. 4 (2002), Heft 13, S. 2161 - 2164
2002Artikel/Aufsatz in Zeitschrift
Chemie
Damit verbunden: 1 Publikation(en)
Titel:
The First Synthetic Receptor for the RGD Sequence.
Autor*in:
Rensing, Stephan;Schrader, ThomasUDE
GND
130213233
LSF ID
16246
ORCID
0000-0002-7003-6362ORCID iD
Sonstiges
der Hochschule zugeordnete*r Autor*in
Erscheinungsjahr:
2002

Abstract:

The combination of an optimized arginine receptor unit with a semirigid linker carrying a strategically placed primary ammonium group leads to the first synthetic receptor in xylylene-based tris(phosphonate) I for RGD peptides. I binds to the free RGD peptide as well as to cyclo(RGDfV) in water with assocn. consts. around 1000 M-1. RGD mimetics such as benzamidine deriv. II are not recognized, rendering I as a new class of synthetic receptors selective for the true RGD sequence in peptides.