Oades, Robert D.; Slusarek, Michael; Velling, Silke; Bondy, Brigitte:
Serotonin platelet-transporter measures in childhood attention-deficit/hyperactivity disorder (ADHD) : clinical versus experimental measures of impulsivity
In: The World Journal of Biological Psychiatry, Jg. 3 (2002), Heft 2, S. 96 - 100
2002Artikel/Aufsatz in ZeitschriftOA Grün
MedizinMedizinische Fakultät » Universitätsklinikum Essen » LVR-Klinikum Essen » Klinik für Psychiatrie, Psychosomatik und Psychotherapie des Kindes- und Jugendalters
Damit verbunden: 1 Publikation(en)
Titel in Englisch:
Serotonin platelet-transporter measures in childhood attention-deficit/hyperactivity disorder (ADHD) : clinical versus experimental measures of impulsivity
Autor*in:
Oades, Robert D.UDE
GND
1208788639
LSF ID
29685
ORCID
0000-0001-6151-5559ORCID iD
Sonstiges
der Hochschule zugeordnete*r Autor*in
korrespondierende*r Autor*in
;
Slusarek, Michael;Velling, Silke;Bondy, Brigitte
Erscheinungsjahr:
2002
Open Access?:
OA Grün
DuEPublico 1 ID
PubMed ID
Sprache des Textes:
Englisch

Abstract in Englisch:

Introduction: Impulsivity in terms of aggression, suicide or poor cognitive control has been associated with low synaptic availability of serotonin (5-HT) in adults and children. However characteristics of the 5-HT transporter have not been studied in children with attention-deficit/hyperactivity disorder (ADHD: combined type) where "impulsivity" is a core symptom. (But it may be noted that low measures of HVA/5-HIAA reported for ADHD children [Oades, 2002] could reflect increased 5-HT metabolism, the opposite to the widespread assumption just described.) Methods: Here, in 20 children with ADHD, we explored the relationship of the density (Bmax) and affinity (Kd) of the platelet 5-HT transporter measured with [3H]paroxetine to both clinical ratings of impulsivity (Conners' Parent Questionnaire), and an experimental measure of impulsivity (the ability to withhold a prepotent response in the "stop-signal" paradigm: See Slusarek et al. 2001, J.Am.Acad.Child Adolesc. Psychiat., 40, 355-363). Results: 1. Decreases of affinity (increased Kd) correlated with a low probability of response inhibition (a cognitive measure of "impulsivity" on the stop-signal task), but not with the clinical ratings of impulsivity (Fig. 1). 2. However, ratings of distractibility and impulsivity correlated with the experimental measure of response-inhibition. 3. In contrast, increased transporter affinity (low Kd) correlated modestly with higher ratings of aggressive and externalising behaviour (CBCL, Child Behavior Check List) - see Fig. 2.. 4. Bmax was not associated with any behavioural score. Conclusions: We conclude that the synaptic availability of 5-HT is under the control of the 5-HT transporter binding site affinity and that low affinity may be related to cognitive impulsivity (distractibility). Increased affinity of the transporter may also be related to conduct disturbance (and externalising behaviour).