Brune, V.; Tiacci, E.; Pfeil, I.; Döring, C.; Eckerie, S.; van Noessel, Cl.; Klapper, W.; Falini, B.; von Heydebreck, A.; Metzler, D.; Bräuninger, A.; Hansmann, M.L.; Küppers, Ralf:
Origin and pathogenesis of nodular lymphocyte-predominant Hodgkin lymphoma as revealed by global gene expression analysis
In: Journal of Experimental Medicine (JEM), Jg. 10 (2008), Heft 205, S. 2251 - 2268
2008Artikel/Aufsatz in ZeitschriftOA Embargo
MedizinForschungszentren » Zentrum für Medizinische Biotechnologie (ZMB)
Damit verbunden: 1 Publikation(en)
Titel in Englisch:
Origin and pathogenesis of nodular lymphocyte-predominant Hodgkin lymphoma as revealed by global gene expression analysis
Autor*in:
Brune, V.;Tiacci, E.;Pfeil, I.;Döring, C.;Eckerie, S.;van Noessel, Cl.;Klapper, W.;Falini, B.;von Heydebreck, A.;Metzler, D.;Bräuninger, A.;Hansmann, M.L.;Küppers, RalfUDE
LSF ID
14392
ORCID
0000-0002-6691-7191ORCID iD
Sonstiges
der Hochschule zugeordnete*r Autor*in
Erscheinungsjahr:
2008
Open Access?:
OA Embargo
Sprache des Textes:
Englisch

Abstract:

The pathogenesis of nodular lymphocyte–predominant Hodgkin lymphoma (NLPHL) and its relationship to other lymphomas are largely unknown. This is partly because of the technical challenge of analyzing its rare neoplastic lymphocytic and histiocytic (L&H) cells, which are dispersed in an abundant nonneoplastic cellular microenvironment. We performed a genome-wide expression study of microdissected L&H lymphoma cells in comparison to normal and other malignant B cells that indicated a relationship of L&H cells to and/or that they originate from germinal center B cells at the transition to memory B cells. L&H cells show a surprisingly high similarity to the tumor cells of T cell–rich B cell lymphoma and classical Hodgkin lymphoma, a partial loss of their B cell phenotype, and deregulation of many apoptosis regulators and putative oncogenes. Importantly, L&H cells are characterized by constitutive nuclear factor κB activity and aberrant extracellular signal-regulated kinase signaling. Thus, these findings shed new light on the nature of L&H cells, reveal several novel pathogenetic mechanisms in NLPHL, and may help in differential diagnosis and lead to novel therapeutic strategies.