Zhou, Kaixin; Asherson, Philip; Sham, Pak C.; Anney, Richard J.L.; Franke, Barbara; Buitelaar, Jan K.; Ebstein, Richard; Gill, Michael; Brookes, Keeley J.; Buschgens, Cathelijne; Cambell, Desmond; Chen, Wai; Christiansen, Hanna; Fliers, Ellen; Gabriëls, Isabel; Faraone, Stephen V. et al:
Linkage to Chromosome 1p36 for Attention Deficit Hyperactivity Disorder Traits in School and Home Settings
In: Biological Psychiatry, Jg. 64 (2008), Heft 7, S. 571 - 576
2008Artikel/Aufsatz in ZeitschriftOA Grün
MedizinMedizinische Fakultät » Universitätsklinikum Essen » LVR-Klinikum Essen » Klinik für Psychiatrie, Psychosomatik und Psychotherapie des Kindes- und Jugendalters
Damit verbunden: 1 Publikation(en)
Titel in Englisch:
Linkage to Chromosome 1p36 for Attention Deficit Hyperactivity Disorder Traits in School and Home Settings
Autor*in:
Zhou, Kaixin;Asherson, Philip;Sham, Pak C.;Anney, Richard J.L.;Franke, Barbara;Buitelaar, Jan K.;Ebstein, Richard;Gill, Michael;Brookes, Keeley J.;Buschgens, Cathelijne;Cambell, Desmond;Chen, Wai;Christiansen, Hanna;Fliers, Ellen;Gabriëls, Isabel;Johansson, Lena;Marco, Rafaela;Mulas, Fernando;Müller, Ueli C.;Mulligan, Aisling;Neale, Benjamin M.;Rijsdijk, Frühling;Rommelse, Nanda N.J.;Uebel, Henrik;Psychogiou, Lamprini;Xu, Xiaohui;Banaschewski, Tobias;Sonuga-Barke, Edmund J. S.;Eisenberg, Jacques;Manor, Iris;Miranda, Ana;Oades, Robert D.UDE
GND
1208788639
LSF ID
29685
ORCID
0000-0001-6151-5559ORCID iD
Sonstiges
der Hochschule zugeordnete*r Autor*in
;
Roeyers, Herbert;Rothenberger, Aribert;Sergeant, Joseph A.;Steinhausen, Hans-Christoph;Taylor, Eric A.;Thompson, Margaret;Faraone, Stephen V.
Erscheinungsjahr:
2008
Open Access?:
OA Grün
DuEPublico 1 ID
Sprache des Textes:
Englisch

Abstract:

Background Limited success has been achieved through previous attention-deficit/hyperactivity disorder (ADHD) linkage scans, which were all designed to map genes underlying the dichotomous phenotype. The International Multi-centre ADHD Genetics (IMAGE) project performed a whole genome linkage scan specifically designed to map ADHD quantitative trait loci (QTL). Methods A set of 1094 single selected Caucasian ADHD nuclear families was genotyped on a highly accurate and informative single nucleotide polymorphism (SNP) panel. Two quantitative traits measuring the children's symptoms in home and school settings were collected and standardized according to a population sample of 8000 children to reflect the developmental nature and gender prevalence difference of ADHD. Univariate linkage test was performed on both traits and their mean score. Results A significant common linkage locus was found at chromosome 1p36 with a locus-specific heritability of 5.1% and a genomewide empirical p < .04. Setting-specific suggestive linkage signals were also found: logarithm of odds (LOD) = 2.2 at 9p23 for home trait and LOD = 2.6 at 11q21 for school trait. Conclusions These results indicate that given large samples with proper phenotypic measures, searching for ADHD genes with a QTL strategy is an important alternative to using the clinical diagnosis. The fact that our linkage region 1p36 overlaps with the dyslexia QTL DYX8 further suggests it is potentially a pleiotropic locus for ADHD and dyslexia.