Chen, Wai; Zhou, Kaixin; Sham, Pak; Kuntsi, Jonna; Campbell, Desmond; Fleischmann, Karin; Knight, Jo; Andreou, Penny; Arnold, Renée; Altink, Mareike; Boer, Frits; Boholst, Mary Jane; Buschgens, Cathelijne; Butler, Louise; Christiansen, Hanna; Asherson, Philip et al:
DSM-IV combined type ADHD shows familial association with sibling trait scores: a sampling strategy for QTL linkage
In: American Journal of Medical Genetics, Part B : Neuropsychiatric Genetics, Jg. 147B (2008), Heft 8, S. 1450 - 1460
2008Artikel/Aufsatz in ZeitschriftOA Grün
MedizinMedizinische Fakultät » Universitätsklinikum Essen » LVR-Klinikum Essen » Klinik für Psychiatrie, Psychosomatik und Psychotherapie des Kindes- und Jugendalters
Damit verbunden: 1 Publikation(en)
Titel in Englisch:
DSM-IV combined type ADHD shows familial association with sibling trait scores: a sampling strategy for QTL linkage
Autor*in:
Chen, Wai;Zhou, Kaixin;Sham, Pak;Kuntsi, Jonna;Campbell, Desmond;Fleischmann, Karin;Knight, Jo;Andreou, Penny;Arnold, Renée;Altink, Mareike;Boer, Frits;Boholst, Mary Jane;Buschgens, Cathelijne;Butler, Louise;Christiansen, Hanna;Fliers, Ellen;Howe-Forbes, Raoul;Gabriëls, Isabel;Heise, Alexander;Korn-Lubetzki, Isabelle;Marco, Rafaela;Medad, She’era;Minderaa, Ruud;Müller, Ueli C.;Mulligan, Aisling;Psychogiou, Lamprini;Sethna, Vaheshta;Uebel, Henrik;McGuffin, Peter;Plomin, Robert;Banaschewski, Tobias;Buitelaar, Jan K.;Ebstein, Richard;Eisenberg, Jacques;Gill, Michael;Manor, Iris;Miranda, Ana;Mulas, Fernando;Oades, Robert D.UDE
GND
1208788639
LSF ID
29685
ORCID
0000-0001-6151-5559ORCID iD
Sonstiges
der Hochschule zugeordnete*r Autor*in
;
Roeyers, Herbert;Rothenberger, Aribert;Sergeant, Joseph;Sonuga-Barke, Edmund;Steinhausen, Hans-Christoph;Taylor, Eric;Thompson, Margaret;Faraone, Stephan V.;Asherson, Philip
Erscheinungsjahr:
2008
Open Access?:
OA Grün
DuEPublico 1 ID
Sprache des Textes:
Englisch

Abstract:

Attention deficit hyperactivity disorder (ADHD) is a discrete clinical syndrome characterized by the triad of inattention, hyperactivity, and impulsivity in the context of marked impairments. Molecular genetic studies have been successful in identifying genetic variants associated with ADHD, particularly with DSM-IV inattentive and combined subtypes. Quantitative trait locus (QTL) approaches to linkage and association mapping have yet to be widely used in ADHD research, although twin studies investigating individual differences suggest that genetic liability for ADHD is continuously distributed throughout the population, underscoring the applicability of quantitative dimensional approaches. To investigate the appropriateness of QTL approaches, we tested the familial association between 894 probands with a research diagnosis of DSM-IV ADHD combined type and continuous trait measures among 1,135 of their siblings unselected for phenotype. The sibling recurrence rate for ADHD combined subtype was 12.7%, yielding a sibling recurrence risk ratio (λsib) of 9.0. Estimated sibling correlations around 0.2–0.3 are similar to those estimated from the analysis of fraternal twins in population twin samples. We further show that there are no threshold effects on the sibling risk for ADHD among the ADHD probands; and that both affected and unaffected siblings contributed to the association with ADHD trait scores. In conclusion, these data confirm the main requirement for QTL mapping of ADHD by demonstrating that narrowly defined DSM-IV combined type probands show familial association with dimensional ADHD symptom scores amongst their siblings