Synthesis of a TMC-95A ketomethylene analogue by cyclization via intramolecular Suzuki coupling.
In: Organic Letters, Vol. 5 (2003), No. 19, pp. 3435 - 3437
Title:
Synthesis of a TMC-95A ketomethylene analogue by cyclization via intramolecular Suzuki coupling.
Author:
Kaiser, MarkusUDE
- LSF ID
- 52590
- ORCID
- 0000-0002-6540-8520
- Other
- connected with university
Year of publication:
2003
Abstract:
A TMC-95A analogue extended at the C-terminus with NlePsi[COCH(2)]Gly-Ala-Ala-NH(2) was synthesized via side-chain cyclization of the linear precursor by a Suzuki cross-coupling reaction in solution to analyze the effect of additional P' residues on the inhibitory potency against yeast proteasome.