Proper insertion of a complex membrane protein in the absence of its amino-terminal export signal
In: The Journal of Biological Chemistry (JBC), Vol. 266 (1991), No. 25, pp. 16530 - 16533
Title:
Proper insertion of a complex membrane protein in the absence of its amino-terminal export signal
Author:
Ehrmann, MichaelUDE
- LSF ID
- 13331
- ORCID
- 0000-0002-1927-260X
- Other
- connected with university
Year of publication:
1991
Abstract:
The MalF protein spans the Escherichia coli cytoplasmic membrane eight times. Deletion of the first transmembrane stretch of MalF, which acts as an export signal, results in a truncated protein that still exhibits high levels of maltose transport activity. These and additional results indicate that the orientation of a membrane protein is not determined by the amino-terminal export signal, topological information is distributed throughout the MalF protein, and insertion of a protein into the cytoplasmic membrane can occur nonsequentially.