Control of replication initiation by the Sum1/Rfm1/Hst1 histone deacetylase
In: BMC Molecular Biology, Band 9 (2008), S. 100
2008Artikel/Aufsatz in Zeitschrift
BiologieChemieFakultät für Biologie » Genetik
Damit verbunden: 1 Publikation(en)
Titel in Englisch:
Control of replication initiation by the Sum1/Rfm1/Hst1 histone deacetylase
Autor*in:
Erscheinungsjahr:
2008
PubMed ID
Scopus ID
Sprache des Textes:
Englisch
Abstract in Englisch:
Replication initiation at origins of replication in the yeast genome takes place on chromatin as a template, raising the question how histone modifications, for instance histone acetylation, influence origin firing. Initiation requires binding of the replication initiator, the Origin Recognition Complex (ORC), to a consensus sequence within origins. In addition, other proteins bind to recognition sites in the vicinity of ORC and support initiation. In previous work, we identified Sum1 as an origin-binding protein that contributes to efficient replication initiation. Sum1 is part of the Sum1/Rfm1/Hst1 complex that represses meiotic genes during vegetative growth via histone deacetylation by the histone deacetylase (HDAC) Hst1.