Rensing, Stephan; Schrader, Thomas:
The First Synthetic Receptor for the RGD Sequence.
In: Organic Letters, Vol. 4 (2002), No. 13, pp. 2161 - 2164
2002article/chapter in journal
Chemistry
Related: 1 publication(s)
Title:
The First Synthetic Receptor for the RGD Sequence.
Author:
Rensing, Stephan;Schrader, ThomasUDE
GND
130213233
LSF ID
16246
ORCID
0000-0002-7003-6362ORCID iD
Other
connected with university
Year of publication:
2002
Appears in
Organic Letters
Title in English (abbreviated):
Org. Lett.
Publisher:
American Chemical Society
in:
Vol. 4 (2002), No. 13, pp. 2161 - 2164
ISSN
1523-7052 Show availability online & print
ISSN
1523-7060 Show availability online & print
ZDB ID
1501522-1
ZDB ID
1458039-1

Abstract:

The combination of an optimized arginine receptor unit with a semirigid linker carrying a strategically placed primary ammonium group leads to the first synthetic receptor in xylylene-based tris(phosphonate) I for RGD peptides. I binds to the free RGD peptide as well as to cyclo(RGDfV) in water with assocn. consts. around 1000 M-1. RGD mimetics such as benzamidine deriv. II are not recognized, rendering I as a new class of synthetic receptors selective for the true RGD sequence in peptides.