- GND
- 1029383219
- LSF ID
- 3560
- ORCID
- 0000-0002-1864-3261
- Sonstiges
- der Hochschule zugeordnete*r Autor*in
- GND
- 130011681
- LSF ID
- 3609
- ORCID
- 0000-0002-3209-4078
- Sonstiges
- der Hochschule zugeordnete*r Autor*in
Abstract in Englisch:
Magnetic nanoparticles (MNPs) are widely known as valuable agents for biomedical applications. Recently, MNPs were further suggested to be used for a remote and non-invasive manipulation, where their spatial redistribution or force response in a magnetic field provides a fine-tunable stimulus to a cell. Here, we investigated the properties of two different MNPs and assessed their suitability for spatio-mechanical manipulations: semisynthetic magnetoferritin nanoparticles and fully synthetic ‘nanoflower’-shaped iron oxide nanoparticles. As well as confirming their monodispersity in terms of structure, surface potential, and magnetic response, we monitored the MNP performance in a living cell environment using fluorescence microscopy and asserted their biocompatibility. We then demonstrated facilitated spatial redistribution of magnetoferritin compared to ‘nanoflower’-NPs after microinjection, and a higher magnetic force response of these NPs compared to magnetoferritin inside a cell. Our remote manipulation assays present these tailored magnetic materials as suitable agents for applications in magnetogenetics, biomedicine, or nanomaterial research.