Ramesh, Vaijayanthi; Stratmann, Nadine; Schaufler, Viktor; Angelov, Svilen D.; Nordhorn, Ilona D.; Heissler, Hans E.; Martínez-Hincapié, Ricardo; Čolić, Viktor; Rehbock, Christoph; Schwabe, Kerstin; Karst, Uwe; Krauss, Joachim K.; Barcikowski, Stephan:
Mechanical Stability of Nano-Coatings on Clinically Applicable Electrodes, Generated by Electrophoretic Deposition
In: Advanced Healthcare Materials, Vol. 11 (2022), No. 23, Article 2102637
2022article/chapter in journalOA Hybrid
ChemistryFaculty of Chemistry » Technische ChemieScientific institutes » Center for Nanointegration Duisburg-Essen (CENIDE)Scientific institutes » Center of Medical Biotechnology (ZMB)
Related: 2 publication(s)
Title in English:
Mechanical Stability of Nano-Coatings on Clinically Applicable Electrodes, Generated by Electrophoretic Deposition
Author:
Ramesh, Vaijayanthi
;
Stratmann, Nadine
;
Schaufler, Viktor
;
Angelov, Svilen D.
;
Nordhorn, Ilona D.
;
Heissler, Hans E.
;
Martínez-Hincapié, Ricardo
;
Čolić, Viktor
;
Rehbock, ChristophUDE
LSF ID
53195
ORCID
0000-0002-4708-5246ORCID iD
Other
connected with university
;
Schwabe, Kerstin
;
Karst, Uwe
;
Krauss, Joachim K.
Other
corresponding author
;
Barcikowski, StephanUDE
GND
129006084
LSF ID
52773
ORCID
0000-0002-9739-7272ORCID iD
Other
connected with university
corresponding author
Year of publication:
2022
Open Access?:
OA Hybrid
Web of Science ID
PubMed ID
Scopus ID
Language of text:
English
Keyword, Topic:
biocompatibility ; biomaterials ; colloids ; deep brain stimulation ; impedance ; laser ablation in liquids

Abstract in English:

The mechanical stability of implant coatings is crucial for medical approval and transfer to clinical applications. Here, electrophoretic deposition (EPD) is a versatile coating technique, previously shown to cause significant post-surgery impedance reduction of brain stimulation platinum electrodes. However, the mechanical stability of the resulting coating has been rarely systematically investigated. In this work, pulsed-DC EPD of laser-generated platinum nanoparticles (PtNPs) on Pt-based, 3D neural electrodes is performed and the in vitro mechanical stability is examined using agarose gel, adhesive tape, and ultrasonication-based stress tests. EPD-generated coatings are highly stable inside simulated brain environments represented by agarose gel tests as well as after in vivo stimulation experiments. Electrochemical stability of the NP-modified surfaces is tested via cyclic voltammetry and that multiple scans may improve coating stability could be verified, indicated by higher signal stability following highly invasive adhesive tape stress tests. The brain sections post neural stimulation in rats are analyzed via laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS). Measurements reveal higher levels of Pt near the region stimulated with coated electrodes, in comparison to uncoated controls. Even though local concentrations in the vicinity of the implanted electrode are elevated, the total Pt mass found is below systemic toxicologically relevant concentrations.