- LSF ID
- 13614
- ORCID
- 0000-0001-5364-6073
- Sonstiges
- der Hochschule zugeordnete*r Autor*in
- GND
- 1208788639
- LSF ID
- 29685
- ORCID
- 0000-0001-6151-5559
- Sonstiges
- der Hochschule zugeordnete*r Autor*in
Abstract in Englisch:
Attention-Deficit/Hyperactivity Disorder (ADHD) is a childhood psychiatric disorder often comorbid with disruptive behavior disorders (DBDs). Here, we report a GWAS meta-analysis of ADHD comorbid with DBDs (ADHD + DBDs) including 3802 cases and 31,305 controls. We identify three genome-wide significant loci on chromosomes 1, 7, and 11. A meta-analysis including a Chinese cohort supports that the locus on chromosome 11 is a strong risk locus for ADHD + DBDs across European and Chinese ancestries (rs7118422, P = 3.15×10−¹⁰, OR = 1.17). We find a higher SNP heritability for ADHD + DBDs (h²SNP = 0.34) when compared to ADHD without DBDs (h²SNP = 0.20), high genetic correlations between ADHD + DBDs and aggressive (rg = 0.81) and anti-social behaviors (rg = 0.82), and an increased burden (polygenic score) of variants associated with ADHD and aggression in ADHD + DBDs compared to ADHD without DBDs. Our results suggest an increased load of common risk variants in ADHD + DBDs compared to ADHD without DBDs, which in part can be explained by variants associated with aggressive behavior.