- GND
- 1155183703
- LSF ID
- 56906
- ORCID
- 0000-0002-0166-2204
- Sonstiges
- der Hochschule zugeordnete*r Autor*in
- GND
- 13043535X
- LSF ID
- 5704
- ORCID
- 0000-0003-2618-818X
- Sonstiges
- der Hochschule zugeordnete*r Autor*in
- LSF ID
- 5703
- ORCID
- 0000-0001-9907-6387
- Sonstiges
- der Hochschule zugeordnete*r Autor*in
- LSF ID
- 57664
- ORCID
- 0000-0003-1415-7714
- Sonstiges
- der Hochschule zugeordnete*r Autor*in
- LSF ID
- 51455
- Sonstiges
- der Hochschule zugeordnete*r Autor*in
Abstract in Englisch:
f Abstract Sexual activity and/or reproduction are associated with a doubling of life expectancy in the long-lived rodent genus Fukomys. To investigate the molecular mechanisms underlying this phenomenon, we analyzed 636 RNA-seq samples across 15 tissues. This analysis suggests that changes in the regulation of the hypothalamic–pituitary–adrenal stress axis play a key role regarding the extended life expectancy of reproductive vs. non-reproductive mole-rats. This is substantiated by a corpus of independent evidence. In accordance with previous studies, the up-regulation of the proteasome and so-called ‘anti-aging molecules’, for example, dehydroepiandrosterone, is linked with enhanced lifespan. On the other hand, several of our results are not consistent with knowledge about aging of short-lived model organisms. For example, we found the up-regulation of the insulin-like growth factor 1/growth hormone axis and several other anabolic processes to be compatible with a considerable lifespan prolongation. These contradictions question the extent to which findings from short-lived species can be transferred to longer-lived ones.